G Protein-Coupled Receptors : Molecular Pharmacology by Georges Vauquelin read book DJV, TXT, EPUB
9780470516478 English 047051647X G protein-coupled receptors (GPCRs) are membrane proteins that transduce a vast array of extracellular signals into intracellular reactions ranging from cell-cell communication processes to physiological responses. They play an important role in a variety of diseases from cancer and diabetes, to neurodegenerative, inflammatory and respiratory disorders. GPCRs are therefore of utmost interest in drug development: over half of all prescription drugs currently on the market act by targeting these receptors directly or indirectly.G Protein-coupled Receptors: Molecular Pharmacology provides a clear summary of the current knowledge in this fast-evolving field. The book sets out with an introduction to signalling molecules and their receptors, and an overview of the technical approaches used to investigate these interactions. Structural, functional and especially pharmacological aspects of GPCRs are then discussed in more detail and much attention is devoted to the analysis and interpretation of experimental data. The now widespread use of recombinant cell lies, receptor mutants and related artifices in drug research is critically evaluated. Special attention is also devoted to topical but often poorly understood concepts, such as insurmountable antagonism, inverse agonism and allosteric interactions.By combining general information with the major state-of-the-art concepts in GPCR-research, this outstanding book equips the reader with the necessary background for understanding and critically evaluating the current literature. Written by two experts from academia and industry, G Protein-coupled Receptors: Molecular Pharmacology offers a unique view of academic and applied approaches aiming to reveal new ideas in pharmaceutical research. The book is of interest to anyone involved in drug development and preclinical research and those who need to function within multi-disciplinary teams in the pharmaceutical industry: from investigators to product managers or clinicians who seek to have a broad mechanistic understanding of drug-receptor interactions. It is also an invaluable resource for final year undergraduate and postgraduate students in pharmacology and cell and molecular biology., G protein-coupled receptors constitute the major cellular targets for pharmaceutical drugs. This book provides a clear summary of the current knowledge regarding this receptor family, with useful information for people involved in pre-clinical research and for people working within multi-disciplinary teams in the pharmaceutical industry (from medical chemistry and molecular biology via pharmacology to drug marketing). The book covers the molecular pharmacology of these receptors and their regulation.�It clarifies the literature and enables the reader to understand the scientific basis of their actions and of the drugs that affect those actions. Much attention is devoted to the analysis and interpretation of experimental data, the evaluation of the now widespread use of recombinant cell lines, receptor mutants and related artifices in drug research, and the analysis of topical but often poorly understood concepts, such as insurmountable antagonism, inverse agonism and allosteric interactions. Importantly, by showing how a pharmaceutical company can adopt academic concepts into its pre-clinical research, this book also provides insight into an early but critical phase in modern drug development. Deals with the entire family of G protein-coupled receptors in general, rather than being restricted to specific subtypes Covers broad topics, but in depth, with considerable reference to the primary literature Written by experts from academia and industry, giving a unique view of basic and applied research on this important receptor family Provides a sound basis for reading research papers on G protein-coupled receptors�and the often complex information brochures on pharmaceutical drugs Useful for experts and those seeking to�be up to speed�on this topic
9780470516478 English 047051647X G protein-coupled receptors (GPCRs) are membrane proteins that transduce a vast array of extracellular signals into intracellular reactions ranging from cell-cell communication processes to physiological responses. They play an important role in a variety of diseases from cancer and diabetes, to neurodegenerative, inflammatory and respiratory disorders. GPCRs are therefore of utmost interest in drug development: over half of all prescription drugs currently on the market act by targeting these receptors directly or indirectly.G Protein-coupled Receptors: Molecular Pharmacology provides a clear summary of the current knowledge in this fast-evolving field. The book sets out with an introduction to signalling molecules and their receptors, and an overview of the technical approaches used to investigate these interactions. Structural, functional and especially pharmacological aspects of GPCRs are then discussed in more detail and much attention is devoted to the analysis and interpretation of experimental data. The now widespread use of recombinant cell lies, receptor mutants and related artifices in drug research is critically evaluated. Special attention is also devoted to topical but often poorly understood concepts, such as insurmountable antagonism, inverse agonism and allosteric interactions.By combining general information with the major state-of-the-art concepts in GPCR-research, this outstanding book equips the reader with the necessary background for understanding and critically evaluating the current literature. Written by two experts from academia and industry, G Protein-coupled Receptors: Molecular Pharmacology offers a unique view of academic and applied approaches aiming to reveal new ideas in pharmaceutical research. The book is of interest to anyone involved in drug development and preclinical research and those who need to function within multi-disciplinary teams in the pharmaceutical industry: from investigators to product managers or clinicians who seek to have a broad mechanistic understanding of drug-receptor interactions. It is also an invaluable resource for final year undergraduate and postgraduate students in pharmacology and cell and molecular biology., G protein-coupled receptors constitute the major cellular targets for pharmaceutical drugs. This book provides a clear summary of the current knowledge regarding this receptor family, with useful information for people involved in pre-clinical research and for people working within multi-disciplinary teams in the pharmaceutical industry (from medical chemistry and molecular biology via pharmacology to drug marketing). The book covers the molecular pharmacology of these receptors and their regulation.�It clarifies the literature and enables the reader to understand the scientific basis of their actions and of the drugs that affect those actions. Much attention is devoted to the analysis and interpretation of experimental data, the evaluation of the now widespread use of recombinant cell lines, receptor mutants and related artifices in drug research, and the analysis of topical but often poorly understood concepts, such as insurmountable antagonism, inverse agonism and allosteric interactions. Importantly, by showing how a pharmaceutical company can adopt academic concepts into its pre-clinical research, this book also provides insight into an early but critical phase in modern drug development. Deals with the entire family of G protein-coupled receptors in general, rather than being restricted to specific subtypes Covers broad topics, but in depth, with considerable reference to the primary literature Written by experts from academia and industry, giving a unique view of basic and applied research on this important receptor family Provides a sound basis for reading research papers on G protein-coupled receptors�and the often complex information brochures on pharmaceutical drugs Useful for experts and those seeking to�be up to speed�on this topic